The University of Sint Eustatius School of Medicine was founded by experienced and highly regarded medical school educators and administrators committed to educating future physicians in a student-centered physician-driven learning environment – one that promotes academic excellence with personal and professional integrity at an affordable cost.

The founders obtained the support for a medical school from the enthusiastic native people and government of the island of Sint Eustatius (Statia). Subsequently, the University of Sint Eustatius was awarded a Charter, which was signed by the Minister of Education, the Minister of Health, and the Governor of Sint Eustatius on April 21, 1999.

On May 27, 1999 the Education Committee on Foreign Medical Graduates (ECFMG) confirmed the eligibility of graduates from the University of Sint Eustatius School of Medicine to register for the United States Medical Licensing Examinations (USMLE).

The University of Sint Eustatius School of Medicine opened the doors to its first class of students on September 1, 1999, and was subsequently listed by the World Health Organization (WHO) in 2000.